Dr. Tigran Khachatryan, MD, PhD.

Intracranial Aneurysms

Understanding Brain Aneurysms: A Patient Guide

This guide provides comprehensive information about brain aneurysms, their treatment, and recovery. Please remember that this information is for educational purposes only and is not a substitute for professional medical advice. Always consult with a qualified healthcare provider regarding your specific medical condition.

What is a Brain Aneurysm?

A brain aneurysm, also known as a cerebral aneurysm or intracranial aneurysm, is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood. Imagine a blister-like bump forming on a blood vessel due to the constant pressure of blood flow pushing against a weakened section. When blood pushes under pressure into this bulge, it can stretch even further, much like a balloon becoming thinner and more likely to pop as it fills with air.

Aneurysms can occur anywhere in the brain, but they are most commonly found along a loop of arteries at the base of the skull, often at branching points where the artery walls may be weaker.

Types and Sizes of Brain Aneurysms

Brain aneurysms are classified by their shape and size:

Aneurysms are also categorized by size:

Most brain aneurysms are small and do not cause symptoms. Up to 6% of people in the U.S. may have an unruptured brain aneurysm. Approximately 10% to 30% of people with a brain aneurysm have multiple aneurysms. They are more common in adults than in children and slightly more common in women than in men.

Causes and Risk Factors

Brain aneurysms develop when the walls of an artery in the brain become thin and/or weak.

Common causes and risk factors include:

Factors that increase the risk of an aneurysm rupturing (bursting) include smoking, high blood pressure, alcohol abuse, and drug abuse (especially cocaine). The size, shape, and location of the aneurysm also affect the risk of rupture, with larger or irregularly shaped aneurysms and those in specific locations (like posterior or anterior communicating arteries) having a higher risk. People over 70, those of Japanese or Finnish heritage, and individuals with multiple aneurysms or a prior bleed are also at higher risk of rupture. Sudden increases in blood pressure, such as from anger or straining, can also contribute to rupture.

Symptoms of a Brain Aneurysm

Most brain aneurysms do not cause symptoms until they become very large or rupture.

Symptoms of an Unruptured Brain Aneurysm (if it presses on nearby nerves or brain tissue):

Symptoms of a Leaking Brain Aneurysm (Sentinel Bleed):

Sometimes, an aneurysm may leak a small amount of blood, which can cause “sentinel” or warning headaches. These are sudden and extremely severe headaches that may occur days to weeks before a more significant rupture.

Symptoms of a Ruptured Brain Aneurysm (a medical emergency):

When an aneurysm ruptures, it is a life-threatening situation and requires immediate medical attention. The most significant symptom is a sudden, extremely severe headache, often described as “the worst headache of my life” and different from any headaches experienced before.

Other symptoms of a ruptured aneurysm may include:

If you or someone you are with experiences a sudden, severe headache, especially when combined with any of these symptoms, seek immediate medical attention by calling 911 or your local emergency number.

Diagnosis of Brain Aneurysms

Most unruptured brain aneurysms are discovered incidentally during brain imaging tests performed for other medical conditions. If a ruptured aneurysm is suspected, healthcare providers will order tests to confirm bleeding in the brain and precisely locate the aneurysm.

Common diagnostic methods include:

Screening for unruptured brain aneurysms is typically only recommended for individuals at high risk, such as those with a family history of brain aneurysms (especially two or more first-degree relatives) or certain genetic conditions like polycystic kidney disease, or Ehlers-Danlos syndrome.

When is Treatment Needed and What are the Risks of Not Treating?

Not all cerebral aneurysms will rupture. The decision to treat an aneurysm is complex and depends on many factors, including the type, size, and location of the aneurysm, its risk of rupture, the patient’s age, overall health, and personal and family medical history, as well as the risks associated with the treatment itself.

Risks of Not Treating a Brain Aneurysm (especially if ruptured):

If an aneurysm ruptures, it spills blood into the surrounding brain tissue, which is a medical emergency. In some estimates, approximately 26% of patients pass from ruptured aneurysm prior to reaching a hospital. Of those reaching a hospital, another 14.5% of patients die from complications of hemorrhage.

Potential dangers and complications of a ruptured aneurysm include:

If the risk of rupture for an unruptured aneurysm is considered low, your doctor may recommend active observation. This involves regular check-ups and monitoring the aneurysm for any changes or growth over time with imaging tests. Lifestyle changes, such as quitting smoking and managing blood pressure, are also crucial to reduce the risk of rupture.

Treatment Options for Brain Aneurysms

The main goal of brain aneurysm treatment is to stop or reduce the flow of blood into the aneurysm, preventing it from enlarging or rupturing. For a ruptured aneurysm, emergency surgery is required. For unruptured aneurysms, treatment may or may not be needed, depending on the factors discussed above. Your healthcare team will recommend the best option based on your specific situation.

The primary treatment techniques are surgical clipping and endovascular coiling. Both carry some risks, such as possible damage to other blood vessels, potential for aneurysm recurrence, rebleeding, and stroke.

Surgical Clipping (Microvascular Clipping)

Surgical clipping is an open brain surgery that has been used for decades to treat aneurysms, demonstrating its safety and effectiveness over time.

Indications:

Clipping can treat most types of aneurysms, even those that have already ruptured. It is often performed on aneurysms that are considered difficult to treat with endovascular approach, such as those with a wide neck at the base, where coiling might not be suitable. Well-clipped aneurysms have an extremely low risk of redeveloping, often resolving the aneurysm permanently.

Endovascular Embolization (Coiling)

Endovascular treatment is a less invasive alternative to open surgery.

Indications:

Coiling is generally preferred for its less invasive nature, making it a potentially safer option for older or high-risk patients who may not tolerate invasive surgery as well. However, it is not suitable for all aneurysms, especially those with a very wide neck or certain shapes, or those that have already ruptured in a way that makes coiling challenging.

Preoperative Care:

You will undergo a thorough pre-admission process, including a history and physical, blood tests, and other diagnostic tests. You may be asked to start additional medications, such as blood-thinning (anticoagulant) medications, which might be needed both before and for extended periods after the procedure to reduce the risk of dangerous clotting. Endovascular coiling also requires general anesthesia.

Procedure:

In this endovascular procedure, the surgeon makes a small incision, usually in the thigh or groin, to access a large artery (like the femoral artery). A hollow plastic tube called a catheter is inserted into the artery and carefully threaded through the vascular system to the site of the aneurysm in the brain. This entire process is guided by X-ray imaging (angiography) and a special contrast dye.

Once the catheter is in position, tiny detachable platinum coils (spirals of wire) are passed through the catheter and released into the aneurysm These coils fill the aneurysm, effectively blocking it from circulation and causing the blood inside to clot, which obliterates the aneurysm. For aneurysms with wide neck, a stent (a wire mesh tube) or balloon may be inserted to help support the blood vessel wall and keep the coils in place.

Postoperative Care:

Since coiling is less invasive, patients generally recover faster than with clipping. Without complications, patients typically spend only a day or two in the hospital after treatment of unruptured aneurysms, often in an intensive care unit (ICU) overnight, and can return to most normal activities within about a week. Recovery from a ruptured aneurysm treated with coiling may still require a longer hospital stay for several weeks.

Common issues during recovery:

Long-term, you may need to continue taking blood-thinning medications. Follow-up imaging of your aneurysm is recommended periodically to evaluate its status, as some aneurysms can recur despite treatment.

Risks and Complications of Endovascular Coiling:

Other Endovascular Procedures

Beyond coiling, other endovascular techniques are used, especially for complex aneurysms:

Flow Diversion Stents: A surgeon inserts a catheter and places a mesh tube (flow diverter) in the part of the blood vessel containing the aneurysm. This mesh diverts blood flow away from the aneurysm, encouraging it to clot and seal, and allowing new cells to grow and reconstruct the parent artery. This is particularly useful for larger aneurysms or those in difficult-to-treat locations.

WEB Device: Through a catheter, a metal mesh-like cube or sphere is placed inside the aneurysm. It functions similarly to a coil by providing a seal-like effect, preventing blood from entering the aneurysm and thus preventing enlargement or rupture. This is an option for patients with complex anatomy around their aneurysm.

 

Additional Treatments for Ruptured Aneurysms:

Beyond securing the aneurysm, a healthcare team will provide additional treatments to manage symptoms and prevent complications after a rupture:

Recovery and Long-Term Effects

Recovery from a brain aneurysm is unique for everyone, but generally, recovery from a ruptured aneurysm is longer and more challenging than from an unruptured one . Older individuals and those with chronic medical problems may also recover more slowly.

Survivors may experience a range of short-term and/or long-term physical, emotional, and cognitive changes. While many deficits improve with time, some can cause significant impairment.

Common long-term effects include:

Rehabilitation services are often crucial for recovery, especially after a ruptured aneurysm. This may include physical, speech, and occupational therapy to help regain function and learn new ways to manage any permanent disabilities. A neuropsychologist or speech-language pathologist can assess cognitive functioning, and cognitive therapists can provide strategies for coping with deficits. Individual psychotherapy can also help manage anxiety, depression, and self-esteem issues.

Many people who have a small unruptured brain aneurysm never develop symptoms and it doesn’t affect their health. For those who survive a rupture, while around 66% may experience permanent brain damage, some recover with little or no disability. A good quality of life is possible, particularly if the aneurysm was treated before a rupture. Survivors and their families are encouraged to maintain hope, as the brain can learn new skills throughout life.

Summary

A brain aneurysm is a weak, bulging spot on a blood vessel in your brain. While many remain small and cause no symptoms, a ruptured aneurysm is a life-threatening medical emergency often characterized by a sudden, severe headache. Diagnosis typically involves imaging tests like CT or MRI scans, or cerebral angiography. Treatment aims to stop or reduce blood flow into the aneurysm, either through surgical clipping (open brain surgery) or endovascular embolization (a less invasive procedure using catheters and coils). The choice of treatment depends on various factors, including the aneurysm’s characteristics and your overall health. Recovery can be a long process, especially after a rupture, and may involve physical, cognitive, and emotional challenges, but rehabilitation services can significantly improve outcomes. Early medical attention for a ruptured aneurysm is crucial for survival and reducing disability.